Myeloma signs and symptoms each individual with multiple myeloma may experience different signs and symptoms prior to their diagnosis and some may experience none.Early stages of the disease …Although there are a number of symptoms of multiple myeloma, about 1 out of every 3 people diagnosed with this cancer have no symptoms.Learn more about possible signs.Some people with multiple myeloma have no signs or symptoms at all.But sometimes multiple myeloma does cause symptoms, including bone pain or weakness, infections, low blood counts, or other …