Function key enzyme in folate metabolism.Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.Catalyzes an essential reaction for de novo glycine and purine synthesis, and …Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase.Key enzyme in folate metabolism.Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.Catalyzes an essential reaction for de novo glycine and purine synthesis, and for dna …
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Dhfr full name:Dihydrofolate reductase alias:21453 number aa:187 uniprot id:P00374 international prot id:Retrieve full protein sequence go terms …Showing 25 of 170 results for p00374 search time:0 ms in all sections (18) in categoryUniprot is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.Keywords assigned by uniprot to proteins because they are involved in a particular biological process.Molecular functioni keywords assigned by uniprot to proteins due to their particular molecular …Megaloblastic anemia due to dihydrofolate reductase deficiency - an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and …