Prior to intubation for a surgical procedure, the anesthesiologist administered a single dose of the neuromuscular blocking agent, succinylcholine, to a 23-year-old female to provide muscular relaxation during surgery and to facilitate the insertion of the endotracheal tube. Following this, the inhalation anesthetic was administered and the surgical procedure completed.


A. Beginning with depolarization at the neuromuscular junction, describe the normal sequence of events which lead to muscle contraction.


B. What prevents acetylcholine (ACh) from accumulating in the neuromuscular junction and causing a sustained contraction in a normal individual?


C. Succinylcholine acts as a depolarizing agent that prevents repolarization of the nerve. Therefore, no further ACh is released until the drug is cleared. Name another site within the neuromuscular junction that might be affected to prevent muscle contraction. (Hint: curare acts by this mechanism.)

Answers

Answer 1

Answer:

A. During general anesthesia drugs are administered to provide hypnosis, ensure analgesia, and skeletal muscle relaxation. The degree of relaxation is assessed by supramaximal train-of-four stimulation of the ulnar nerve and measuring the electromyogram response of the adductor pollicis muscle.

B. ACh is hydrolyzed by the enzyme acetylcholinesterase, which is on the postsynaptic membrane, with its active site facing the synaptic cleft. Succinylcholine acts as a depolarizing agent that prevents repolarization of the nerve. Therefore, no further ACh is released until the drug is cleared. Name another site within the neuromuscular junction that might be affected to prevent muscle contraction. (Hint: curare acts by this mechanism.) Curare competes with ACh for the receptor proteins on the muscle cell membrane, thus reducing the size of the end-plate potential. Thus, curare can be used as a muscle relaxant during anesthesia.

C.Thus, curare can be used as a muscle relaxant during anesthesia.

Explanation:

Answer 2

The normal sequence of events initiates with the beginning of an action potential by the motor nerve. Due to this, depolarization and calcium ion release. The mechanism of actin and myosin leads to sarcomere shortening.

What do you mean by Depolarization?

Depolarization may be defined as a state in which the cell's internal charge becomes less negative and more positive with respect to the outside.

A drug Botulinum toxin prevents acetylcholine (ACh) from accumulating in the neuromuscular junction and causing a sustained contraction in a normal individual.

Curare is a non-depolarizing neuromuscular blocking agent.  The nerve axon is the name of another site within the neuromuscular junction that might be affected to prevent muscle contraction.

Therefore, it is well described above.

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Related Questions

3. True or False:
Greg calls Louisa names every day in class. She is embarrassed with
the insults. He gets his friends to call her names too. This is not a one-time
thing. It continues throughout the school year. This is an example of
bullying.
Answer:​

Answers

Answer:

True.

Explanation:

Bullying is defined as repeated emotional or physical abuse of an individual.

True, this would be bullying

Why is MRSA difficult to treat

Answers

Answer:

MRSA infections are more difficult to treat than ordinary staph infections. This is because the strains of staph known as MRSA do not respond well to many common antibiotics used to kill bacteria. ... Given enough time, bacteria can change so that these antibiotics no longer work well.

Explanation:

Staph can usually be treated with antibiotics. But over the decades, some strains of staph -- like MRSA -- have become resistant to antibiotics that once destroyed it. MRSA was first discovered in 1961. It's now resistant to methicillin, amoxicillin, penicillin, oxacillin, and other common antibiotics known as cephalosporins.

1. Compare and contrast airborne transmission and droplet transmission.

in 4 sentences!!

2.How are transmission-based precautions different from standard precautions?

Answers

Answer:

Airborne transmission is when germs float through the air after a person talks, coughs, or sneezes. Droplet transmission is when germs travel inside droplets that are coughed or sneezed from a sick person enters the eyes, nose, or mouth of another person. Both can contaminate someone when it gets in a persons eyes, nose, or mouth. But only droplets stick to surfaces and can infect someone who touches the same surface.

Explanation:

thats only the answer for Q1

why do people respond in different ways to the same kind of pain

Answers

The reason why some people are more sensitive than others comes down to how our body modulates pain from the skin to the brain and the structure of the brain itself. It all begins with a bunch of sensory receptors detecting an unpleasant stimuli. These are transformed into pain signals that are then conducted throughout the central nervous system via a series of 'pain pathways'.

Explanation:

watch the sonic movie YOU NEED TO SEE IT he reason why some people are more sensitive than others comes down to how our body modulates pain from the skin to the brain and the structure of the brain itself. It all begins with a bunch of sensory receptors detecting an unpleasant stimuli. These are transformed into pain signals that are then conducted throughout the central nervous system via a series of 'pain pathways'.

Which of the following is not part of the mucosa associated lymphatic tissue?
Select one:
a. the appendix
b. lingual tonsils
c. axillary nodes
d. Peyer's patches

Answers

The answer is C axillary nodes

Nurses at a local hospital recently conducted a survey of patients about their expectations of nurses. Which of the following was NOT an opinion shared by the majority of responding patients?

a. Seventy-three percent thought nurses should keep their hair tied back and off their shoulders.
b.Ninety-one percent thought that nurses should not have long fingernails.
c. Eighty-eight percent thought nurses should spend less time at the nurse's station.
d. Fifty-five percent thought it difficult to distinguish a nurse from other medical staff in the hospital.

Answers

Final answer:

The opinion not held by the majority of the survey's respondents was that it is difficult to distinguish a nurse from other medical staff, as it was just over half at 55%, making it significantly lower than the other options.

Explanation:

The opinion NOT shared by the majority of responding patients in the nurse survey was d. Fifty-five percent thought it difficult to distinguish a nurse from other medical staff in the hospital. A majority is typically considered to be more than 50%, however, in the context of survey opinions, a dominant majority is often implied to mean a significantly larger percentage agree on an aspect. Since option d is barely over half and significantly lower than the other percentages mentioned, it makes it the least agreed upon statement and not considered a majority opinion similar to the others with much higher percentages.

A patient must take 300 milligrams of medication at lunch. The
medication is available in capsules of 60 milligrams each. How
many capsules should the patient take?
2 capsules
3 capsules
4 capsules
5 capsules

Answers

Answer:

5 capsules

Explanation:

Dividing the dose of 300 milligrams by 60 milligrams in each capsule results in the need for 5 capsules to be taken.

What are some of the effects that DEPRESSANTS can have upon an
individual? (3 answers)
• Drowsiness
•euphoria
•pain preventions
•increased energy
•increased sexual arousal
•relaxed feeling
•increased metabolism

Answers

Answer:

drowsiness, increased sexual arousal, increased metabolism

Explanation:

Slow brain function

Slowed pulse and breathing

Lowered blood pressure

Poor concentration

Confusion

Fatigue2

Dizziness

Slurred speech

Fever

Sluggishness

Visual disturbances

Dilated pupils

Disorientation, lack of coordination

Depression

Difficulty or inability to urinate

Addiction

The dental assistant had a 3/4 bottle of disinfectant and a 1/3 bottle of another cleaning solution. How much solution does the dental assistant have?

Answers

Answer:

1 1/12

Explanation:

You add both fractions together to find how much solution he has in total.

Final answer:

To find the total amount of solution, add the fractions 3/4 and 1/3. The dental assistant has a total of 1 and 1/12 of solution.

Explanation:

To find the total amount of solution the dental assistant has, we need to add the amounts of the two bottles. The dental assistant has a 3/4 bottle of disinfectant and a 1/3 bottle of another cleaning solution. To add these fractions, we need to find a common denominator. The least common multiple of 4 and 3 is 12, so we can rewrite 3/4 as 9/12 and 1/3 as 4/12. Adding these fractions gives us a total of 13/12 or 1 and 1/12.

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In the middle of the night, you are dispatched for the report of a sick person at the bus stop at the corner of Pennsylvania Avenue and 6th street. As you arrive on the scene, you find a middle aged man pacing back and forth at the bus stop. He is shouting that he needs to go to Albuquerque tonight to stop his pain. He then asks you why you are there.
What types of conditions contribute to or cause a situational Crisis?
What are the four phases of a situational crisis?
What are the three communication tools you can use to help communicate with this patient?

Answers

Types of conditions contribute to or cause a situational Crisis:

Medical conditionsPsychiatric illnessesPhysical conditions or traumaSituational stressors

Four phases of a situational crisis:

High anxietyAnger and frustrationDenial modeRemorse

Three communication tools you can use to help communicate with this patient

RestatementRedirectionEmpathy

Explanation:

Situational crisis refers to some sudden, unusual, unexpected stressor or events in life which makes it extremely difficult to cope with. These events include any loss of close or dear ones, severe physical violence or verbal abuse, severe physical injury or accident, loss of job, interpersonal losses etc.

Victims of this crisis often suffer with high anxiety, anger, frustration.

Appropriate communication skills with underlying empathy based on restatements and redirection of the victim helps to cope with this crisis.

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