using the gas pedal analogy explain the impact on the cell cycle of a proto-oncogene versus an oncogene

Answers

Answer 1

Using the gas pedal analogy, the proto-oncogene would be an accelerator since they promote cell division and deregulate apoptosis, while tumor suppressor would be the brakes since they constrain the progress of the cell cycle and induce cell apoptosis. An oncogene is, therefore, when the accelerator is stuck in down position and the brakes are not working.






Answer 2

Using the gas-pedal analogy oncogene, when the accelerator is stuck in down position and the brakes are not working.

Proto-oncogene:

promote cell division and deregulate apoptosis. Considered as an accelerator

Tumor suppressor genes:

Stop the progress of the cell cycle and induce cell apoptosis.Considered as brakes.

Hence, we can say that oncogene, when the accelerator is stuck in down position and the brakes are not working.

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Related Questions

Plant A and Plant B are heterozygous for a gene that expresses their tall trait (Tt). Upon crossing, what is expected in the offspring, assuming random chromosome segregation? A) They will always have an allele that expresses the tall trait. B) They will always have an allele that expresses the short trait. C) They are more likely to have an allele that expresses the tall trait than one that expresses the short trait. D) They are more likely to have an allele that expresses the short trait than one that expresses the tall trait.

Answers

C. There is a 75% chance the offspring will express the tall trait with a genotype of TT or Tt, while there is only a 25% chance the offspring will display the short phenotype, with a genotype of tt.
the answer is c)they are more likely to have an allele that expresses the short trait

Felicia wants to follow the "check your steps" rules for food safety. when she prepares high-risk foods, she avoids cross contamination, cooks raw foods to their safe internal temperatures, and chills leftovers within 30 minutes after serving them. after eating one of her meals, felicia and her dinner guests developed a food-borne illness. based on this information, which step did she fail to take?

Answers

The "check your steps" rules for food safety are rules recommended by United States Department of Agriculture (USDA) to prevent food poisoning. The four steps include clean, separate (to avoid cross contamination), cook and chill. Based on the information given in the question, Felicia failed to take the clean step which involves the frequent washing of hands, utensils, and surfaces.

Which statement about DDT best shows how science has been impacted by society?

Answers

The answer to the above question is that ddt was used in wwii to control malaria and typhus, it was in the second half of the World War II. First synthesized in 1874, DDT's insecticidal action was discovered by the Swiss chemist Paul Hermann Müller in 1939.

The ingestion of which nutrient type results in the greatest food-induced thermogenesis?

Answers

Proteins

Proteins is the most thermogenic of all nutrients and macromolecules we eat. Thermogenesis is the generation of due to digestion and metabolism of food.  Studies shows that  proteins tend to be more thermogenic that carbohydrates and fats. This means that the calorie given of by proteins is converted and released as heat and less available for storage. This means that the stored energy formed from protein much of it is released as heat and unlike other macromolecules few of it is converted to a energy that can be stored.

Fungus bodies are made up of thin, threadlike filaments called _____.

Answers

Final answer:

Fungal bodies are primarily made up of hyphae, which form a larger structure called a mycelium. These fungi, with their cell walls made mostly of chitin, have both vegetative and reproductive stages, where fruiting bodies can produce spores for reproduction.

Explanation:

Fungus bodies are composed of thin, threadlike filaments known as hyphae. These hyphae are the building blocks of the fungal structure. Most fungi, except for yeasts which grow as single cells, develop these filamentous structures. The collection of these hyphae is referred to as a mycelium. The cell wall of fungi is made largely of chitin and functions similarly to the cell walls in plants. Fungi can be multicellular organisms that have both vegetative and reproductive stages. During the vegetative stage, the fungus exists in a network of hyphae, and in the reproductive stage, it may form more visible structures like mushrooms. These reproductive structures, known as fruiting bodies or sporocarps, are involved in the production of spores for fungal reproduction.

The mycelium of a fungus can span a considerable area and remain mostly hidden from view, as is the case with some large fungal organisms like the "humongous fungus" Armillaria ostoyae. Fungi play a crucial role in ecosystems as decomposers by producing enzymes that help break down various organic materials, allowing them to absorb nutrients.

the systemic system carries blood to the:
a. body cells
b. pulmonary cells
c. epidermis
d. main arteries

Answers

The systemic system carries blood to the body cells.
a. body cells

Blood from left ventricle pass through Aorta to various body organs to supply them with oxygenated blood and take away deoxygenated blood. this part of double circulation of blood is known as systematic circulation.


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What is a difference between the oxidation of coal when it is burned and the oxidation of glucose during cellular respiration?

A) Cellular respiration is an endothermic reaction.
B) Energy is released only during the burning of fossil fuels
C) Complete oxidation takes place only during the burning of fossil fuels
D) Energy is produced and stored during cellular respiration.

Answers

energy is produced and stored during respiratory respiration 
D IS UR ANSWER

Ans. (D). Energy is produced and stored during cellular respiration.

Oxidation of glucose during cellular respiration is better than burning of coal in the presence of oxygen. It is because burning coal generates heat, which is not generally useful and cannot be captured by cells as energy source.

On the other hand, cellular respiration involves complete oxidation of glucose, which provides so much energy. This energy is stored by the cell for its cellular activities.

Thus, the correct answer is option (D).

The effect of human disturbance on animal populations is?
A. Density-dependent
B. Density-independent
C.unobservable
D. Stabilizing

Answers

Final answer:

Human disturbances can have density-dependent effects on animal populations because they can alter conditions like food availability and habitat space, which can more severely impact populations when they are at higher densities. Option A

Explanation:

The effect of human disturbance on animal populations can be categorized as either density-dependent or density-independent. These terms describe how factors affect populations depending on their density. Human disturbances, such as habitat destruction or pollution, can act in both density-dependent and independent ways.

Density-independent factors impact populations regardless of density. Examples include natural disasters or climate events, and they can affect animal populations uniformly. An example might be a pesticide that kills a certain percentage of a caterpillar population irrespective of how many caterpillars there are.

Density-dependent factors have varying impacts depending on the population density. High population densities might lead to depletion of resources like food, resulting in starvation or increased disease transmission, thereby reducing population size. In contrast, human disturbances such as overfishing or habitat fragmentation can have density-dependent effects because they more severely impact populations at higher densities where competition for diminished resources is greater. Therefore, the answer to the question is A. Density-dependent.

What best describes the same pattern of Tides on Earth throughout the day?

Nocturnal tides
Spring tides
Semidiurnal tides
Neap tides

Answers

The correct answer is C. Semidiurnal Tides

These tides happen all through the day.

Brainliest plz!!!!!!!! I really need it!

Answer:

c

Explanation:

took the test

To be considered acid rain, precipitation would have to be?

Answers

Acid rain is caused by a chemical reaction that begins when compounds like sulfur dioxide and nitrogen oxides are released into the air. These substances can rise very high into the atmosphere, where they mix and react with water, oxygen, and other chemicals to form more acidic pollutants, known as acid rain.
To be considered acid rain, precipitation would have to be at a pH level less than 5.0

Which of the following is a possible litter for two heterozygous black mice
A) three black mice
B) five black offspring
C)four white offspring and one black
D) all of the above

Answers

Answer:

The answer is D

Explanation:

Final answer:

In genetics, heterozygous refers to two different genes in a pair. For two heterozygous black mice breeding, a probable pattern is 75% black pups and 25% white. So, it is possible for all provided litters (A, B, and C) to occur.

Explanation:

In genetic terms, heterozygous indicates that a pair of genes in a particular position of the chromosomes, one inherited from each parent, are different. In the case of the two heterozygous black mice, it means each of them carries one allele for black fur and one for white. When they breed, each offspring will inherit one allele randomly from each parent, leading to a possible distribution of 75% black mice and 25% white mice. Therefore, all of the options (A, B, and C) presented are possible outcomes for a single litter of heterozygous black mice offspring.

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Abnormal side pockets in a hollow organ, such as the intestine, are called:

Answers

Abnormal side pockets in the hollow organ, such as the intestine, are termed as "diverticula."

Diverticula are small pouch-like structures that form in the walls of certain hollow organs in the body, most commonly in the gastrointestinal tract. The word "diverticula" is the plural form of "diverticulum." They can occur in various organs, but the most common location is the colon, specifically in the sigmoid colon, which is the lower part of the large intestine.

The development of diverticula is associated with a condition called "diverticulosis." Diverticulosis typically occurs over time and is often related to increased pressure within the intestine. Several factors can contribute to the formation of diverticula, including:

Low-fiber diet: A diet low in fiber can lead to constipation and increased pressure in the colon during bowel movements. This pressure can cause weak spots in the intestinal wall to bulge out, forming diverticula.

Aging: As people age, the walls of the intestine may become weaker, making them more susceptible to the development of diverticula.

Genetics: There might be a genetic predisposition for some individuals to develop diverticulosis.

Lifestyle factors: Factors such as lack of physical activity, obesity, and smoking may also contribute to the development of diverticula.

Diverticulitis can be mild or severe, and in severe cases, it may lead to complications such as abscess formation, perforation (a hole in the intestine), or fistula formation (an abnormal connection between organs).

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Urinary obstruction in the lower urinary tract triggers changes to the urinary system to compensate for the obstruction. what is an early change the system makes in its effort to cope with an obstruction?

Answers

The early change that the system makes in an effort to cope with an obstruction is that the stretch receptors in the bladder wall become hypersensitive. Urinary tract obstruction is a blockage that inhibits the flow of urine through the urinary tract, including the kidneys, ureters, bladder, and urethra. The blockage mat be partial or complete. In response to the obstruction the urinary system is capable of undergoing adaptive changes or responses to compensate for the obstruction.

The end product of a biosynthetic pathway often acts to block the initial step in that pathway. this phenomenon is called:

Answers

the answer is 

D.) FEEDBACK INHIBITION.

According to the law of conservation of energy, energy cannot be created but it can be destroyed. true false

Answers

false it can neither be created or destroyed but can only be transferred or changed

Answer:

false

Explanation:

Discuss why heart rate equals pulse rate at rest and after exercise.

Answers

When a heart beats, blood is pushed through the body, causing a change in blood pressure and a pulse in main arteries. In healthy individuals, this means the heart rate is often synchronized with the pulse. However, heart rate and pulse rate are technically different because a heart rate measures the rate of contractions (heartbeats) of the heart, whereas a pulse rate measures the rate of palpable blood pressure increases throughout the body.

For individuals who have certain heart conditions, the heart may not efficiently push blood through the body with each contraction. These individuals have a pulse that is lower than their heart rate. Other factors affecting heart rate and blood pressure include body mass, athleticism, obesity, medication, alcohol use, and smoking. For most people, each contraction produces a pulse, so the pulse is an effective way to measure heart rate. Baseline heart rates are resting heart rates, measured by taking the pulse.

While in exercise for most people, heart rate and pulse will not go above 220 beats/minute during these times, nor should that high of a heart rate be accepted for more than minutes based on activity level and duration as a variety of studies reported by Cleveland Clinic indicate that repetitive, excessive heart rate experienced, for example, by repeat marathon runners, may cause heart muscle damage leading to arrhythmia (irregular heart palpitations) and an assortment of heart conditions.

 Normal, healthy adults who are reasonably fit and not overweight, and do not smoke or drink heavily, will have resting heart rates between 60 and 100 beats per minute (bpm); their pulse will reflect this. Average, healthy teenager heart rates are the same as those for adults, while children under 10 years of age experience higher heart rates and pulses:

·         Newborns (1-30 days old) = 70-190

·         Infants (1-11 months = 80-160

·         Toddlers (1-2 years old) = 80-130

·         Preschoolers (3-4 years old) = 80-120

·         Elementary Age (5-10 years) = 70-115

Athletes share the same range with others in their age group, but teen and adults who are excessively active and fit may have resting heart rates and pulses as low as 40 bpm.

 

 

A concerned male athlete brings a clear, red urine specimen to the physician's office.
a. would you expect to see rbcs in the microscopic examination?

Answers

Yes, normally red urine indicates "hematuria," or blood in the urine. This is due to RBCs if blood leaking into the urine and can have multiple causes.
There is another condition called rhabdomyolysis, that is severe, but it normally produces an orange-colored urine, and it due to strenuous exercise and dehydration.

Final answer:

The presence of red blood cells (RBCs) in a clear, red urine specimen would be expected upon microscopic examination and suggests hematuria, which can indicate conditions such as urinary tract injury or kidney issues. Hematuria needs to be distinguished from hemoglobinuria, where only free hemoglobin is present without RBCs.

Explanation:

If a male athlete brings in a clear, red urine specimen to the physician's office, the expectation upon microscopic examination of the urine would be to potentially observe red blood cells (RBCs). The presence of RBCs in the urine, known as hematuria, can be indicative of various medical conditions such as nephritis, trauma to the urinary tract, tuberculosis of the kidney, or kidney stones. Conversely, hemoglobinuria, which is the presence of free hemoglobin in the urine without RBCs, may occur in conditions like malaria, kala-azar, or typhoid. The distinction between the two conditions is important for accurate diagnosis and treatment planning.

The presence of white blood cells (WBCs) in the urine, for instance, suggests an infection or inflammation in the urinary tract, as seen in conditions like urinary tract infections (UTIs) or nephritis.

Under normal conditions air moves from ______ pressure system to a ______ pressure system

Answers

Under normal conditions air moves from higher pressure system to a lower pressure system
Air moves to lower pressure. This concept can be observed in the lungs and heart. When you trying to inhale, the muscle in ribs or diaphragm will pull the rib cage and decrease its pressure up to -1mm Hg. This will cause the air from atmosphere enter the lungs. 
In expiration, the muscle will relax and the air pressure inside lungs will become +1 mm Hg, makes the air pushed out.

What type of relationship is between remora and a shark?

Answers

It is symbiosis, but also called a commensalism relationship because the remora is getting its food and the shark has no benefit.

Students are having an end of the semester party, which includes drinking alcohol, having snacks, and swimming. a student was found floating in the pool. which action by first responders is most important? immobilizing the cervical spine establishing iv access and infusing warmed fluids evacuating water from the lungs securing the airway and providing ventilation

Answers

The correct answer is "securing the airway and providing ventilation".
It has been proven that the first priority when dealing with drowning victims is to try and resuscitate the victim. This is done by securing the airway and providing ventilation. Especially, in this prehospital stage, the first responders should assess the airway, breathing, circulation and cervical spine. After securing that the victim has normal breathing and circulation, the healthcare professional should focus on correcting any abnormal physiological functions, such as hypoxia and hypothermia.

Why is a 100% fat-free diet unhealthy?
a. fat-free foods have unnatural additives to make them taste better.
b. dietary fat is necessary for carbohydrate absorption.
c. essential fatty acids must be obtained from the diet.
d. the body cannot obtain enough energy from food if no fat is present?

Answers

Low-fat diets may adversely affect levels of blood lipids, LDL pattern, HDL, and triglycerides, potentially raising the risk of heart disease.

The diagram represents one of Mendel’s laws or principles of inheritance. mc014-1.jpg Which law or principle does the diagram represent? dominance independent assortment segregation genetics

Answers

Segregation.

The correct answer is "C"! There ya go fam!

The answer would be C. segregation.

State the meaning of inertia and explain how inertia affects the hair cell processes of the inner ear during acceleration and deceleration

Answers

Inertia refers to the tendency of matter such as the endolymph fluid in the vestibular apparatus to remain at rest if at rest, or if in motion to keep moving in the same direction.  When a person begins to spin, the inertia of the endolymph causes the cupula to bend in the opposite direction. However, as the spin continues the inertia of the endolymph is overcomed and the cupula straightens. The endolymph and the cupula are moving in the same direction and at the same speed such that if deceleration occurs , the greater inertia of the endolymph causes it to continue moving in the original direction of spinand to bend the cupula in the same direction thus causing stimulation of the underlying hair cells.

Inertia is a property that resists changes in velocity and affects the inner ear's hair cells during motion. The inner ear structure, which includes the utricle and saccule, responds to linear acceleration, while the semicircular canals detect angular acceleration. Alcohol impacts the vestibular system, often causing a sensation of spinning known as 'the spins'.

Inertia is the resistance of any physical object to any change in its velocity. This includes changes to the object's speed, or direction of motion. An example of inertia affecting the human body is found within the hair cell processes of the inner ear during acceleration and deceleration.

The utricule and saccule detect linear acceleration. They are composed of maculae formed by hair cells embedded in a viscous gel-like substance, called the otolith. The otolith, which contains calcium carbonate crystals, has greater inertia compared to the maculae. When the head moves, gravity causes the otolith to move separately, bending the stereocilia attached to hair cells. This movement depolarizes some hair cells while hyperpolarizing others, and the resulting pattern informs the brain about the head's position and movement.

The semicircular canals function to detect angular acceleration. They contain hair cells whose stereocilia project into a gelatinous structure called the cupula. When the head turns or rotates, the movement of fluid within the canals shifts, bending the stereocilia, and sending signals to the brain. This system is sensitive to changes in velocity rather than constant motion.

Alcohol consumption can affect the vestibular system and lead to a sensation known as the spins. Alcohol alters the density and viscosity of the fluid in the semicircular canals, making the hair cells more sensitive and prone to send signals to the brain that create a sensation of spinning even when one is not moving.

Which is your closest relative? a slime mold the malaria parasite a mushroom an apple tree?

Answers

I believe that the answer is a mushroom. The mushroom and animals are both eukaryotes with nuclei and complex structures inside their cell membrane.These features were considered the main similarity until scientists discovered that both the fungi and animals contain lanosterol which no plant has it or anything similar to it. This is why a fungi like mushroom would be considered a close relative to humans.

A model cell with damaged DNA was created to explain the importance of checkpoints in a cell cycle. The G2 checkpoint accidentally failed to work during experimentation. What do you think is the likely consequence of this failure?
A.The cell divided and created two cells with repaired DNA.
B.The cell couldn’t divide, and cell division stopped.
C.The cell died before it could complete division.
D.The cell divided and created two nonidentical cells.
E.The cell continued to divide uncontrollably to create more damaged cells.

Answers

E. The cell continued to divide uncontrollably to create more damaged cells.

The correct answer is option E.The cell continued to divide uncontrollably to create more damaged cells.

The G 2 check point checks if the replicated genetic material in the DNA is error free or not. In case, there are errors present in the DNA of the cell, the G2 checkpoint doe not allow the cell to undergo mitosis until it is repaired. Hence, a damage to the G2 checkpoint would lead to the division of the cell with damaged DNA and the cell will continue to divide and produce more damaged cells.

Much of the energy used by people in both rural and urban areas is used for the same thing. However, ____________________ is practiced almost exclusively in rural areas, and can be energy intensive.

Construction Manufacturing Agriculture

Answers

The answer should be agriculture.

Agriculture means farming of crops or the rearing of animals, either for their own use or for commercial purposes. Rural area means a place away from the city, opposite of urban areas, with little buildings and most likely have a smaller population.

On the other hand, construction and manufacturing most likely is going to be common in urban area, as urban area is more likely to have more buildings being built and most of the products are made in the factories in urban areas. Therefore, the only activity that is almost practiced exclusively in rural area is agriculture. Urban areas don't have much space and well environment for agriculture activities.

Agriculture activities can be energy consuming as some may require different machines to help with farming processes such as harvesting or irrigation.
Much of the energy used by people in both rural and urban areas is used for the same thing. However, agriculture is practiced almost exclusively in rural areas, and can be energy intensive.

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WILL GIVE OUT BRAINLIEST!!
1. In a hypothetical city such as Gotham City, the temperature is dropping and the skies are clearing. How would the barometer be changing?

2. On another day in Gotham City, the temperature is rising, the skies are getting cloudy, and some precipitation begins to fall. How would the barometer be changing?

Answers

for one it would be rising and for two dropping


1.Barometric pressure would be increasing.

2.The pressure would be dropping


 

What type of rna copies the dna in the nucleus and then takes the copy to the ribosomes?

Answers

The type of RNA that copies DNA and takes the copy to the ribosomes is "mRNA."

Messenger RNA (mRNA) is the type of RNA that copies the DNA in the nucleus and carries the information to ribosomes in the cytoplasm for protein synthesis.

Transcription is the process by which mRNA is synthesized from the DNA template. After transcription, mRNA exits the nucleus and enters the cytoplasm, where ribosomes read its genetic code to synthesize proteins. The two other main forms of RNA involved in protein synthesis are ribosomal RNA (rRNA), which forms part of the structure of ribosomes, and transfer RNA (tRNA), which brings amino acids to the ribosome to be incorporated into the protein being synthesized.

How could I measure the rate of photosynthesis in a scientific experiment that'll test the effect of light intensity on the rate of photosynthesis with an Elodea plant?

Answers

There are a few key methods to calculate the rate of photosynthesis. These include:

1) Measuring the uptake of CO2

2) Measuring the production of O2

3) Measuring the production of carbohydrates

4) Measuring the increase in dry mass


As the equation for respiration is almost the reverse of the one for photosynthesis, you will need to think whether these methods measure photosynthesis alone or whether they are measuring the balance between photosynthesis and respiration.

To measure the rate of photosynthesis in an experiment testing the effect of light intensity using an Elodea plant, you can use the method of counting oxygen bubbles released from the plant over a set period.

We can follow these steps to measure the rate of photosynthesis:

Set Up the Experiment: Place a piece of Elodea in a beaker filled with water and a small amount of sodium bicarbonate (to provide a source of carbon dioxide).Light Source: Position a light source at different distances from the plant to vary the light intensity. Use a ruler to measure and adjust the distance accurately.Measure Oxygen Production: Count the number of oxygen bubbles released from the cut end of the Elodea stem over a fixed period (e.g., 5 minutes). Oxygen production is a direct indicator of the photosynthesis rate.Control Variables: Keep other factors constant, such as temperature, CO₂ concentration, and water quality, to ensure that changes in the rate of photosynthesis are due to light intensity alone.Data Collection: Record the number of bubbles at each light intensity level. Repeat the experiment several times for accuracy and calculate the average rate of photosynthesis.Analysis: Plot the data on a graph with light intensity on the x-axis and the number of oxygen bubbles (rate of photosynthesis) on the y-axis to visualize the relationship.

By using this method, you can effectively measure the rate of photosynthesis in response to varying light intensities.

Biology help please!
3. for a person who writes with his or her left hand, the muscles involved in writing are controlled by
A. the left hemisphere of the cerebrum
B. the right hemisphere of the cerebrum
C. both
D. neither,

Answers

The brain is a very complex organ in humans. Although we still have a lot to learn about it, decades of studies in both living and dead humans had revealed that the brain is crosswired, meaning the right side of the brain controls the left side of the body and viceversa. It’s also the part of the brain associated with arts and our creativity. Therefore the answer is B

The answer is B. the right hemisphere of the cerebrum

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Use equal intervals to make a frequency table for the average number of movies per person. You do not need to show tally marks. Country Average Number of Movies Turkey 0.5 Japan 1.2 UK 1.3 Finland 1.3 Austria 1.5 Germany 1.8 Spain 2.2 Sweden 2.2 Denmark 2.2 Switzerland 2.5 France 2.5 Norway 3.0 Canada 3.0 US 4.5 How can so many different substances and molecules be created from just over 100 different elements? Khafre was a son of Khufu. He also had a pyramid built, but it was not as big as his fathers. The volume of the Pyramid of Khafre is about 2,115,072 cubic meters, and its height is about 136 meters. Approximate the length of each side of the base.Could you work it out also! Addison bought 5/6 yard of ribbon. She used 1/4 yard of ribbon to decorate her scrapbook. How much ribbon did she have left after decorating the scrapbook? When heavy rain ruined the banana crop in central america, the price of bananas rose from $1.00 a pound to $2.00 a pound. growers sold fewer bananas, but their total revenue remained unchanged. the quantity of bananas decreased increased by nothing percent. >>> answer with a whole number? Identify the sentence as simple, compound, complex, or compound-complex. A passport is not currently necessary for residents of the United States or Canada crossing the border, but one may be required in the near future. A. complex B. compound-complex C. simple sentence D. compound sentence In the case of U.S. v. Nixon, what did the court ultimately decide about the president with regard to rule of law? Mycorrhizal associations are symbiotic interactions between __________ and __________ which of the following is responsible for transporting oxygen throughout the body Read the passage on the left to answer the following questions: PLS HELP LOTS OF POINTS BRAINLY AS WELL Which statement BEST summarizes the passage?A)A man is held prisoner inside the home of an old childhood friend.B)A man enters the dreadful home of an old acquaintance only to find it abandoned.C)A man enters the home of an old acquaintance and grows more apprehensive the further he travels.D)A man enters the dreadful home of an old acquaintance and has an unpleasant encounter with the family doctor.EliminateShaking off from my spirit what must have been a dream, I scanned more narrowly the real aspect of the building. Its principal feature seemed to be that of an excessive antiquity. The discoloration of ages had been great. Minute fungi overspread the whole exterior, hanging in a fine tangled web-work from the eaves. Yet all this was apart from any extraordinary dilapidation. No portion of the masonry had fallen; and there appeared to be a wild inconsistency between its still perfect adaptation of parts, and the crumbling condition of the individual stones. In this there was much that reminded me of the specious totality of old wood-work which has rotted for long years in some neglected vault, with no disturbance from the breath of the external air. Beyond this indication of extensive decay, however, the fabric gave little token of instability. Perhaps the eye of a scrutinizing observer might have discovered a barely perceptible fissure, which, extending from the roof of the building in front, made its way down the wall in a zigzag direction, until it became lost in the sullen waters of the tarn.2 Noticing these things, I rode over a short causeway to the house. A servant in waiting took my horse, and I entered the Gothic archway of the hall. A valet, of stealthy step, thence conducted me, in silence, through many dark and intricate passages in my progress to the studio of his master. Much that I encountered on the way contributed, I know not how, to heighten the vague sentiments of which I have already spoken. While the objects around mewhile the carvings of the ceilings, the sombre tapestries of the walls, the ebon blackness of the floors, and the phantasmagoric armorial trophies which rattled as I strode, were but matters to which, or to such as which, I had been accustomed from my infancywhile I hesitated not to acknowledge how familiar was all thisI still wondered to find how unfamiliar were the fancies which ordinary images were stirring up. On one of the staircases, I met the physician of the family. His countenance, I thought, wore a mingled expression of low cunning and perplexity. He accosted me with trepidation and passed on. The valet now threw open a door and ushered me into the presence of his master.3 The room in which I found myself was very large and lofty. The windows were long, narrow, and pointed, and at so vast a distance from the black oaken floor as to be altogether inaccessible from within. Feeble gleams of encrimsoned light made their way through the trellised panes, and served to render sufficiently distinct the more prominent objects around; the eye, however, struggled in vain to reach the remoter angles of the chamber, or the recesses of the vaulted and fretted ceiling. Dark draperies hung upon the walls. The general furniture was profuse, comfortless, antique, and tattered. Many books and musical instruments lay scattered about, but failed to give any vitality to the scene. I felt that I breathed an atmosphere of sorrow. An air of stern, deep, and irredeemable gloom hung over and pervaded all. Given: ABCD is a parallelogram mA = 60 ; BK AD AK = KD; Perimeter of ABCD = 24 Find: BD. 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