He human gene egfr located on chromosome 7 is a proto-oncogene that codes for a growth factor cell surface receptor. the binding of growth factors to this receptor can lead to cell proliferation. hypothesize what potential impact a mutated egfr allele will have on a cell. give one possible impact and explain your answer

Answers

Answer 1

A mutated EGFR gene may cause the up-regulation of the growth factor receptors. This causes an abnormally high levels growth factor response to occur even when growth factors have not bound the receptor causing the epidermal cells to proliferate. This unregulated growth causes cancer such as adenocarcinoma.


Answer 2

The mutated EGFR allele leads to development of cancer.

Further Explanation:

Proto-oncogenes are the genes that induces normal cells to become cancerous if they are mutated which is dominant in nature.  

The mutated proto-oncogene becomes oncogene when mutated. Most of the time proto-oncogene encodes proteins which stimulates the cell to divide, inhibit cell differentiation and prevents cell death and these processes is crucial for normal development and maintenance of organs. But oncogenes shows higher cell division, decreased cell differentiation and cell death inhibition which is the characteristics of cancer cell.

EGFR or Epidermal Growth Factor Receptor functions in regulating the epithelial tissue developmental process and homeostasis. In cancer cells EGFR is inappropriately activated in the cancer cell due to point mutations or transcriptional upregulation. EGFR has also been marked as the biomarker of resistance in tumors.

EGFR are involved in canonical EGFR signaling pathway which is ligand and kinase-dependent.

When there is absence of stimulation, the EGFR is normally found to be in auto-inhibited, incompetent state in plasma membrane. Binding of ligand allows the receptor dimerization which further leads to EGFR kinase activation.

EGFR signaling can be disrupted due to EGFR gene amplification or mutations. Mostly the mutations occurs in glioblastoma and lung cancer. These genetic lesion is accompanied by increase in EGFR ligand production.in certain cases genetic changes determines the abnormal trafficking of EGFR that leads to enhanced signaling and tumor development.

Learn more:

1. Learn more about cell https://brainly.com/question/1579016

2. Learn more about cell cycle https://brainly.com/question/1600165

3. Learn more about meiosis https://brainly.com/question/94813

Answer Details:

Grade: College biology

Subject: Biology

Chapter: Cancer biology

Keywords:

Proto-oncogenes , genes, normal cells, cancerous, dominant, oncogene, proteins, cell, tissues, organs, EGFR, Epidermal Growth Factor Receptor, homeostasis, resistance, ligand, plasma membrane, signaling, tumor.


Related Questions

Which statement best describes the composition and function of proteins in organisms?

Answers

long chains of amino acids used for building, repair, and maintenance.

Answer:

The answer is Proteins are molecules formed by amino acids and fulfill an essential function for life since they are highly necessary for the growth of the organism.

Explanation:

Proteins are molecules formed by amino acids that are linked by a type of bonds known as peptide bonds. All proteins are composed of Carbon, Hydrogen, Oxygen, Nitrogen and most of them also contain Sulfur and Phosphorus.

Proteins fulfill an essential function for life since they are highly necessary for the growth of the organism, in addition to allowing cells to maintain their integrity, defend against external agents, repair damage, control and regulate functions, among others.

explain three ways how humans cause loss to biodiversity

Answers

The major causes of biodiversity decline are land use changes, pollution, changes in atmospheric CO2 concentrations, changes in the nitrogen cycle and acid rain, climate alterations, and the introduction of exotic species, all coincident to human population growth. For rainforests, the primary factor is land conversion. Climate will probably change least in tropical regions, and nitrogen problems are not as important because growth in rainforests is usually limited more by low phosphorus levels than by nitrogen insufficiency. The introduction of exotic species is also less of a problem than in temperate areas because there is so much diversity in tropical forests that newcomers have difficulty becoming established (Sala, et al., 2000).

Our bodies do not make starch, but we often eat plant foods which contain starch which we digest into _____________, the building block that is used to make starch.

Answers

The correct answer is glucose. 

Glucose is the major carbohydrate that can be absorbed and used by humans for energy. In animals, glucose is stored as glycogen in the liver and the muscle tissue in contrast to plants wherein they store glucose as amylose and amylopectin (also known as starch). In digestion of starch, it will start with the saliva where the enzyme salivary amylase will break it down to smaller molecules of starch and limit dextrins. These will be further broken down in the intestines using the pancreatic amylase forming di and trisaccharides. These di and trisaccharides will be metabolized by brush border enzyme to eventually produce glucose (and other monosaccharides that can be absorbed such as fructose and galactose).

What is an environmental purpose of buying hunting licenses?

Answers

To keep populations of wild animals stable... I just answered it and its right

a. At the end of replication, two ____ copies of DNA exist.
b. Both copies consist of one ____ strand plus one ____ strand.

Answers

the answer to your question is two DNA molecules. 2 both copies consist of one new chain and one old chain nucleotides. half of the chain is part of the original DNA molecule the other brand new molecule

Question 20 1. the energy to move chromosomes during mitosis is provided by
a. centrioles.
b. dna polymerization.
c. migration of the centrosomes.
d. atp.
e. formation of the cell plate.

Answers

that would be d.ATP :)

A plants biomass mainly comes mainly from nutrients in the soil that are taken up by the plants roots

Answers

This statement is true

Answer: False

The mass of the plant is based on compounds made from carbon. Carbon is not absorbed from the roots, it is absorbed through the leaves in form of carbon dioxide. The process involved in the primary stage is photosynthesis. Roots absorb water and minerals or ions. These are used in reaction of the plant cells. Rest the biomass is made from glucose, which is converted into other compounds by series of reactions taking place in plant cell.

which of the following would be the best way to determine whether a cell belonged with Archaea or bacteria?

Answers

Hey there

the answer is

 a Archean is a single celled microorganism and has no cell nucleus  
and Bacteria constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a number of shapes, ranging from spheres to rods and spirals 

so im going to say D as the answer

Hopes this helps u :)  

The nurse is preparing to reinforce instructions to a pregnant client about nutrition. the nurse plans to include which instruction in this client's teaching plan?

Answers

The nurse should plan to include this instruction in the client's teaching plan: THE NUTRITIONAL STATUS OF THE MOTHER SIGNIFICANTLY INFLUENCES FETAL GROWTH AND DEVELOPMENT.
As part of the teaching plan for the pregnant woman, the nurse should include instructions about nutrition and make the client to be aware that the food she eat will affect how the baby in her womb grows and develops. 
Final answer:

In her instructions about nutrition, a nurse should highlight the significance of a balanced diet, the importance of prenatal care, and the risk factors of obesity during pregnancy. It could also be beneficial to introduce the client to health education and nutrition programs.

Explanation:

When educating a pregnant client about nutrition, the nurse should emphasize the importance of a balanced diet that provides the necessary nutrients for both mother and fetus. This balanced diet should include a variety of foods to ensure all essential nutrients are met, as it will help maintain proper bodily functions, good health, and reproductive capability.

Prenatal care also plays an essential role in a successful pregnancy, as it helps monitor the health of both mother and fetus. This includes consultations on pregnancy planning and potentially on taking vitamins such as folic acid, which can help prevent certain birth defects.

Emphasis should be placed on the harmful implications of obesity during pregnancy, which can increase the risk of complications such as type-2 diabetes and cardiovascular disease. Additionally, it is beneficial to expose the client to health education programs like the Supplemental Nutrition Assistance Program (SNAP), which has shown success in improving at-home diets of participants, leading to healthier children.

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A 60-year-old man is unable to walk more than 100 yards without experiencing severe chest pain in his left leg; the pain is relieved by resting for 5-10. he is told that the arteries of his leg are becoming occluded with fatty material and is advised to have the sympathetic nerves serving that body region severed. explain how such surgery might help to relieve this man's problem

Answers

This is a case of peripheral artery disease which is described as the occlusion of the arteries of the extremities due to atherosclerosis causing ischemia and pain of the affected extremity. The pathophysiology works similarly in angina wherein there is occlusion of the coronary arteries. The resection of the sympathetic nerves (sympathectomy) innervating the affected leg will decrease the tone of the arteries leading it to vasodilate and increase the vessel diameter thus relieving the occlusion and eventually the ischemia.
Final answer:

The man is experiencing peripheral artery disease due to atherosclerosis. The suggested surgery, severing the sympathetic nerves, may allow more blood flow in the arteries reducing the pain. Alongside lifestyle changes, surgical treatments like angioplasty, endarterectomy, or coronary bypass might be employed based on the severity of the occlusion.

Explanation:

The 60-year-old man you described is likely experiencing a condition called peripheral artery disease, linked to atherosclerosis, where the arteries become blocked by fatty plaque deposits. This causes pain during movement, as the muscles cannot get sufficient blood flow. The suggested surgery involves severing the sympathetic nerves in that region, which could provide relief because these nerves control the contraction and relaxation of the arteries. If relaxed, the arteries may allow more blood flow, reducing pain after walking.

Treatment typically involves lifestyle changes, including weight loss, smoking cessation, regular exercise, and a diet low in sodium and saturated fats. Medications to reduce cholesterol and blood pressure may also be prescribed. If the arteries' occlusion is severe, a surgical solution like angioplasty could be employed, where a catheter is inserted into the vessel at the point of narrowing and inflated to widen the opening. A small mesh tube called a stent may be inserted to keep the vessel patent. In an endarterectomy, plaque is surgically removed from the arteries. Alternatively, in a coronary bypass procedure, a non-vital superficial vessel from elsewhere in the body, or a synthetic vessel, is used to create a bypass around the occluded artery.

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​the vitamin that is responsible for regulating the absorption and metabolism of calcium and phosphorus for healthy bones and teeth is vitamin ____. ​e

Answers

The answer is vitamin D. This is actually a group of vitamins of similar molecular structure responsible for facilitating increased absorption of calcium, magnesium and phosphate from the gut. The most important of the vitamin D compounds are vitamin D3 and D2. While vitamin D can be obtained from your diet and supplements, the major source of vitamin D is from a chemical reaction dependent on skin exposure to the sun.

Choose the properties that are characteristic of true solutions. Select as many as apply.

Answers

Is there any choices?
The answers are light beam passes through invisibly and particles are dissolved. youre welcome lol

Opiate drugs bind onto the same receptor sites as the body's own endorphins. therefore, opiate drugs tend to

Answers

I believe that opiates tend to relieve pain. Opiates are drugs used to treat pain derived from the opium plant. They are highly addictive, so they pose the threat of opiate addiction (including opioid addiction) to any person who takes the drug for a prolonged period of time. They also include illegal drugs such as heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, morphine and codeine among others

Oligodendrocytes and schwann cells generate a fatty substance known as

Answers

They generate a fattu subtance known as myelin.
Final answer:

Oligodendrocytes in the CNS and Schwann cells in the PNS generate a fatty substance called myelin. The myelin sheath acts as insulation for neurons, facilitating the transmission of electrical signals along axon segments.

Explanation:

The fatty substance generated by oligodendrocytes in the Central Nervous System (CNS) and Schwann cells in the Peripheral Nervous System (PNS) is known as the myelin sheath. Myelin is a lipid-rich layer that surrounds an axon, acting as insulation. This helps to facilitate the transmission of electrical signals along the axon. Oligodendrocytes can reach out to multiple axon segments, whereas a Schwann cell wraps around a segment of only one axon.

Think of the myelin sheath similar to the pastry wrapped around a hot dog for 'pigs in a blanket' or similar food. The cell is wrapped around the axon several times with little to no cytoplasm between the cell layers. For oligodendrocytes, the rest of the cell is separate from the myelin sheath as a cell process extends back toward the cell body, providing insulation for other axon segments in the area. For Schwann cells, the outermost layer of the cell membrane contains cytoplasm and the nucleus of the cell.

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A genetic study conducted over two generations found that the frequencies of genotypes in the first generation were aa: 0.36, aa: 0.48, aa: 0.16. in the second generation, genotype frequencies remained the same. according to hardy–weinberg equilibrium, what can we assume?

Answers

For the genotypic frequency to remain the same over generations, then according to Hardy-Weinburg, the following five assumptions are presumed;

1.       That the population is large enough for sampling hence there is no genetic drift

2.       Natural selection is not acting on the population

3.       No gene flow between the population being studied with another population occurred either through migration etcetera

4.        No/negligible mutations occurred

5.       Mating between individuals of the population is occurring randomly


Describe how draping is completed for a procedure that enters the ocular orbit

Answers

For a procedure that enters the ocular orbit, draping is completed by covering the head with a double-thickness half sheet and two towels or appropriate disposable head drapes. Then placed an eye sheet to the operative site using a fenestrated eye sheet that measures 14 inches square, with a center opening of 2 1/2 x 3 inches or by using adhesive backed aperture drape that extends over the body.

 

 

Which portion of the heart wall is responsible for the pumping action?

Answers

The heart is composed of three layers: (1) pericardium, (2) myocardium, and (3) endocardium.

The correct answer for this question is the myocardium. The myocardium is composed of cardiac muscle tissue that responds to the pacemaker activity of the heart (originates from the sinuatrial node) and performs rhythmic contractions that corresponds to a person's heartbeat. 

The pericardium forms the pericardial sac wherein the pericardial fluid is located. The endocardium lines the atria and ventricles as well as contributes to the formation of the heart valves.

Click an item in the list or group of pictures at the bottom of the problem and, holding the button down, drag it into the correct position in the answer box. Release your mouse button when the item is place. If you change your mind, drag the item to the trashcan. Click the trashcan to clear all your answers.
Complete the following diagram by placing the graphics on their appropriate spots.

Answers

Answer:

Correct answer in attached file.

Explanation:

This would be the correct answer because, in order for a daughter to have two x chromosomes with the recessive b trait, she would need to obtain one b from each parent. So, each parent (the circle and the square in the diagram) would have to have the trait.

Jose and Sarah are running in the cross country meet. Their skeletal and muscular systems work to move them through the course. As they run, they breathe faster and harder and their heart rate increases.

This illustrates that body systems

A)work together.
B)work independently.
C)all have the same function.EliminateD)have no connection to one another.

Answers

A) they work together.
On USAtestprep The answer is A) working together 

Streptococci can give you strep throat. They are unicellular, prokaryotes that contain a cell wall. They are so small that a powerful microscope must be used to see them. In which kingdom would you place them? Protista Fungi Eubacteria

Answers

the answer is Eubacteria

Answer:

C

Eubacteria

Explanation:

got it right in edg (see pic)

hope this helps :)

What occurs if a t cell binds to an antigen and the t cell does not receive a co-stimulatory signal?

Answers

The correct answer is that "the T cell enters a state of anergy".

The activation of T cells requires two signals: (1) antigen specific signal presented by an antigen presenting cell (either a macrophage or a dendritic cell) that activates t cell receptors and (2) co-stimulatory signals that is not antigen specific but rather found in the plasma membrane of the antigen presenting cell (i.e. CD28). In the absence of a co-stimulatory signal, the t cell will enter a state of anergy or the inability to produce an immune response toward an offending antigen.

Which property of connective tissue is fundamental to its function of binding tissues and organs? cells that contain actin and myosin mostly made of protein fibers regenerative properties tightly packed cells

Answers

B. Mostly made of protein fibers

Ans.

Connective tissue is defined as tissue that connects body organs and tissue and provides them support.These tissues are mainly made up of three types of components, cells, ground substance or matrix, and protein fibers (collagenous and elastin fibers).

The property that makes it able to function in binding of tissues and body organs is presence of collagen protein fibers.These fibers are made up of thin collagen filaments that provides support for the tissue and the organs, to which it connects.

Thus, the correct answer is option option). 'mostly made up of protein fibers.'

Under what conditions might a person with rh- blood develop rh agglutinins

Answers

A person who has rh- blood can develop rh agglutins through;

1. Pregnancy.
2. Transfusion.
3. Exposure to blood.

Agglutination is termed as clumping of particles. It is the process which occurs when an antigen is mixed with its corresponding antibody known as isoagglutinin.
When people are being given blood transfusion of wrong blood group then the antibodies will react incorrectly with the transfused blood group, then the erythrocytes clump up and stick together which causes them to agglutinate.
Final answer:

A person with Rh- blood may develop anti-Rh agglutinins if exposed to Rh+ blood through transfusion or pregnancy with an Rh+ baby. Sensitization and a subsequent exposure can cause hemolytic disease of the newborn, but this condition is preventable with RhoGAM injections.

Explanation:

A person with Rh-negative (Rh-) blood may develop anti-Rh agglutinins, or antibodies, under certain conditions. This process is known as sensitization. It occurs when a person with Rh- blood is exposed to Rh-positive (Rh+) blood, which can happen through a blood transfusion with Rh-incompatible blood or during pregnancy when an Rh- woman gives birth to an Rh+ baby. The first exposure to Rh+ blood cells typically does not cause a reaction; however, the immune system starts to generate anti-Rh antibodies. Upon a second exposure to Rh+ blood, such as during a subsequent pregnancy with an Rh+ fetus, these antibodies can cross the placenta, resulting in agglutination and hemolysis of the fetal red blood cells, a condition known as hemolytic disease of the newborn (HDN) or erythroblastosis fetalis. This can be severe and life-threatening to the fetus but can be prevented with the injection of RhoGAM during and after the first pregnancy.

How does the nervous system determine the strength of stimulus?

Answers

frequency of action potentials hopes this helps :))

Which term best describes an organism that has the genotype ff?'?

Answers

The term given is in small letter.
Infact, both are in small letters...
So the organism received the recessive traits...
So, ff can be described as ‘RECESSIVE’
Final answer:

An organism with the genotype 'ff' is homozygous recessive, expressing the recessive phenotype associated with that gene, such as constricted pod form in pea plants, if 'f' stands for a recessive trait.

Explanation:

An organism that has the genotype ff is best described as homozygous recessive. This means that both alleles for a given trait are the same and are the recessive form. In the context of Mendelian genetics, if 'f' represents a recessive allele for a particular gene, an individual with the genotype 'ff' would express the recessive phenotype if no other gene interactions alter this expression. This is in contrast to heterozygous (Ff) or homozygous dominant (FF) individuals, where the recessive trait would not be phenotypically expressed if 'F' is a dominant allele.

For example, if 'F' represents a dominant allele for full pod form and 'f' represents a recessive allele for constricted pod form in pea plants, then an organism with genotype 'ff' would exhibit the constricted pod form. As observed in Mendel's hybridization experiments, these genetic principles explain why certain traits appear in specific patterns across generations.

When one opens a door, which part of the brain is responsible for sending signals to the arm muscles, causing one to open the door?

Answers

Answer M1 motor cortex

Why is isopropyl alcohol a better mobile phase than h2o for permanent markers?

Answers

Rubbing alcohol or isopropyl alcohol is used because it dissolves the dye better than water. The ink from a permanent marker is insoluble in water because of its components such as pyrrolidone, glyceride, and colorant. These ingredients make permanent ink waterproof because they make are nonpolar whereas water is polar. As a rule of thumb, only like materials can combine.

Which of these is an example of food engineering apex?

Answers

the answer for apex would be, The development of irrigation


Food engineering is exemplified by the optimization of freezing processes for packaged foods, the creation of modified foods with enhanced nutritional values using biotechnology, and the development of specialized food products like MREs and astronaut meals.

An example of food engineering can be seen in the design and optimization of freezing processes for food products. Engineers need to consider the best type of freezing equipment and operational parameters to ensure that food is frozen quickly and efficiently, preserving its quality and safety. A critical part of this process is to account for the packaging material, which can resist heat transfer and increase freezing time.

Additionally, the creation of modified foods, such as calcium-fortified orange juice or breads enriched with B vitamins, also represents food engineering. These foods have been enhanced using biotechnology to improve nutritional value and health attributes. Another aspect of food engineering is the development of food products aimed at specific needs, such as MREs (Meals Ready-to-Eat) for military personnel or specialized foods for astronauts, which are safe to store, easy to prepare in low-gravity environments, and nutritionally balanced.

Fertilizer use and crop rotation with legumes both increase the availability of which of the following nutrients in soil

Answers

The answer to this question would be Nitrogen

plz help!!! lots of points!!!
Which option describes what the U.S. Green Building Council has created?
(A)government control over all engineering design materials
(B)partnerships with LEED and other government organizations
(C)sustainable materials that can be used for any design process
(D)guidelines to simplify the certification process for sustainable building and construction

Answers

Hey there budd!

Your question is stated above: Which option describes what the U.S. Green Building Council has created?

Based from my information, I know for a fact the the answer would NOT be option D. The government would not to simplify the certification process for sustainable building and construction because they want (high) quality people working for them, not people who have low certificates to work for the government.

I (seriously) believe that the correct answer to this question would actually be the first option. (A) Government control over all engineering design materials. So, this would show you that the U.S. Green Building Council has created a government to watch over and control everything that is being designed.

I hope this helps you!

Answer:

guidelines to simplify the certification process for sustainable building and construction

Explanation:

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Why were some women against voting rights for women?A.They were afraid of what men would do to them. B.They were afraid to vote. C.They were too busy with household work to vote.D.They believed it went against the natural order of things. Which sentence must be revised to eliminate the preposition at the end? A.If no one answers the door, then please let yourself in.B.The top steps are fine, but be careful of the slippery stairs below.C.Where are Katelyn and Ella walking to?D.Do you know what Naveen was talking about? A large frog eats 500 flies a day. How many flies does a frog eat in a 365-day year? Choose the correct simplification of the expression (2x + 4y)(3x 7y). 6x2 2xy 28y2 6x2 + 26xy 28y2 6x2 + 26xy + 28y2 6x2 + 26xy 28y2 Why was the committee of public safety allowed to terrorize France during the reign of terror 100 POINTSEveryone kept telling me that a summer trip to Hawaii would be the highlight of my summer. It was the worst week of my life.My big sister sobbed the whole way to the airport because she would miss her boyfriend. What an overreaction! The trip was six days long! Hed be there when she got back, but she was convinced she had a ticket to planet loneliness, not Maui. After listening to her cry for six hours, I wanted to send her somewhere else, too.She started to cheer up when she saw the beaches, but that didnt last long. Our twin little brothers, who often egged each other on to bad decisions, made possibly their worst choice ever: testing how many days they could spend at the beach without wearing any sunscreen. Answer: not even one full day before they were so lobster-red that we had to go to the emergency clinic! After that, the beach was off limits. It was totally ridiculous that I couldnt go swimming just because they were too silly to wear sunscreen. I wasnt going to make that mistake. But it didnt matter. Mom decreed, No beach for anybody.So lucky me, I spent my vacation watching Hawaiian TV and eating take-out food, rubbing lotion on my brothers blisters and watching my sister sniffle and text her boyfriend. What a vacation! Next time I visit Hawaii, I think Ill go alone.a-How does the narrators choice of words express her attitude toward her little brothers?b-Words like lobster-red and rubbing lotion on my brothers blisters show how worried she is about them.Words like totally ridiculous and decreed show how she and her brothers both felt that their mom spoiled the trip for them.c-Phrases like highlight of my summer and lucky me indicate how grateful she is to have gone on the trip with her little brothers.d-Phrases like worst choice ever and too silly convey her frustration. 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I need a lot of help. in the figure below,angle y and angle x from vertical angles.angle y forms a straight line with 80 angle and the 60 angle Please help me I have no idea what to do. 300 pounds of oranges were purchased at $0.24 per pound. The desired markup is 50% based on selling price, but 21% spoilage is expected. What should the selling price per pound be? (Round your answer to the nearest cent) Symbols placed above vowels and some consonants in order to aid pronunciation are called _____. Sierra sawed 10 1/2 inches off the end of a board. the remaining board was 37 1/2 inches long. how long was the boared that sierra started with? please explain answer