What is the most common method of carbon dioxide transport? what is the most common method of carbon dioxide transport? dissolved in the plasma chemically bound to hemoglobin as carbaminohemoglobin chemically bound to hemoglobin as oxyhemoglobin as bicarbonate ions in the plasma?

Answers

Answer 1
The appropriate answer is as a bicarbonate ions in the plasma. Carbon dioxide is transported in the blood from the tissues to the lungs in three different ways. some of it is transported dissolved in the plasma, some is transported as carbaminohemoglobin and other as bound to proteins. However most carbon dioxide is transported as bicarbonate; as blood flows through the tissues, carbon dioxide diffuses into red blood cells, where it is converted into bicarbonate.
Answer 2
Final answer:

The most common method of carbon dioxide transport is as bicarbonate ions in the plasma.

Explanation:

Carbon dioxide can be transported through the blood via three methods. It is dissolved directly in the blood, bound to plasma proteins or hemoglobin, or converted into bicarbonate. The majority of carbon dioxide is transported as bicarbonate ions in the plasma.

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Related Questions

How might mendel's conclusions have differed if he had studied two traits determined by alleles carried on the same chromosome?

Answers

He would not have seen segregation of alleles and so would not have Mendel's Law of Segregation.
A dihybrid cross would give in the F2 a ratio of 3:1 instead of 9:3:3:1.(assuming no crossing over)

If Mendel had studied two traits determined by alleles carried on the same chromosome, then he would not have observed independent assortment.

What is Mendel's law of independent assortment?

According to Mendel's law of independent assortment, The zygote inherits distinct features from several alleles independently of one another.

Mendelian dihybrid crosses are an excellent illustration of autonomous assortment. Round green and wrinkled yellow are two novel pairings that indicate the genes responsible for seed color and shape are independently sorted. He observed nine plants with round yellow, round green, wrinkled yellow, and wrinkled green seeds in the 9:3:3:1 ratio in the F2 generation.

Therefore, Mendel would not have observed independent assortment, if he had studied two traits determined by alleles present on the same chromosome.

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Why is it more practical to prepare karyotypes by looking at somatic diploid cells rather than haploid gametes?

Answers

Because both sets of chromosomes, which are present in somatic diploid cells, need to be examined.

The haploid gametes only contain half of the chromosomes. That is why it is more practical to prepare karyotypes by looking at somatic diploid cells rather than haploid cells.

What is karyotyping?

It is a test for examining the chromosomes in a given sample of cells. This test is used for identifying the genetic problems that have resulted in a disorder or disease. Almost any tissue can be used for performing this test. These can include Amniotic fluid, Blood, Bone marrow, or even placenta.

The test is performed by placing the sample in a special dish or a tube. It is then allowed to grow in the laboratory. Then the cells are later taken from the new sample and are then stained.

A microscope is then used for to examine the size, shape, and number of chromosomes in the sample of cells. The sample that is stained is photographed for showing the arrangement of the chromosomes. This arrangement is called a karyotype.

This can be used for identifying certain problems through the number of chromosomes or the arrangement of the chromosomes. Thousands of genes are stored in DNA and the basic genetic material is present in the chromosome.

Therefore, the haploid gametes only contain half of the chromosomes. That is why it is more practical to prepare karyotypes by looking at somatic diploid cells rather than haploid cells.

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Why is the largest dna fragment band found closest to the well in which it was placed?

Answers

Because of the molecular weight of DNA, the larger fragment DNA is heavier and cannot move fast through the gel and found near to well whereas the small fragments with small molecule weight can move fast through the gel pores.
Final answer:

In agarose gel electrophoresis, larger DNA fragments migrate less due to the molecular sieve effect of the gel matrix which impedes their movement. Thus, they are found closer to the well they were loaded into, while smaller fragments move farther away.

Explanation:

The largest DNA fragment band is found closest to the well in because it travels slower through the gel during agarose gel electrophoresis. During this process, DNA fragments are loaded into a gel and an electric field is applied. Due to its negative charge, DNA moves towards the positive electrode. However, the gel matrix forms a molecular sieve, impeding the movement of larger molecules, allowing smaller fragments to pass through more readily. Hence, larger DNA fragments migrate less, staying closer to the well from which they were loaded, while smaller fragments travel farther.

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A skeletal muscle deprived of adequate atp supplies will _____. a skeletal muscle deprived of adequate atp supplies will _____. sequester all free calcium ions into the sarcoplasmic reticulum immediately relax enter a state where actin and myosin are unable to separate fire many more action potentials than usual and enter a state of "rigor"

Answers

A skeletal muscle deprived of adequate ATP supplies will enter a state of rigor mortis.

When a skeletal muscle is deprived of adequate ATP supplies, it enters a state known as "rigor mortis." Rigor mortis is a natural post-mortem phenomenon that occurs in the muscles of a deceased organism, typically a human body.

Here's how it happens: ATP is essential for muscle contraction and relaxation. During life, ATP is constantly produced and used to power the cross-bridge cycling between the protein filaments actin and myosin in muscle cells. This cycling allows muscles to contract and relax as needed for various movements.

However, when an organism dies, ATP production ceases, and the available ATP is depleted. Without ATP, the myosin heads that are firmly attached to actin cannot detach from it. As a result, the muscle becomes rigid and locked in a contracted state. This rigidity is what we observe as rigor mortis.

The onset of rigor mortis typically occurs a few hours after death, peaks around 12-24 hours after death, and then gradually dissipates as the muscle proteins break down due to enzymatic processes and decomposition. It's important to note that rigor mortis is a temporary condition and does not last indefinitely. The exact timing and duration of rigor mortis can vary depending on factors like temperature, pH levels, and the individual's overall health at the time of death.

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Final answer:

If a skeletal muscle lacks adequate ATP, it enters a state of rigor where the muscle remains contracted because the actin and myosin proteins cannot separate. The muscle does not immediately relax, sequester all free calcium ions, or fire many more action potentials.

Explanation:

A skeletal muscle deprived of adequate ATP (adenosine triphosphate) supplies will enter a state known as rigor. This is because ATP is essential for muscle contraction and relaxation. Without enough ATP, the actin and myosin proteins within the skeletal muscle fibers cannot detach from each other, causing the muscle to remain in a contracted state, or rigor. Therefore, the muscle does not relax immediately or sequester all free calcium ions into the sarcoplasmic reticulum, and it does not fire many more action potentials than usual. Skeletal muscles need ATP to function correctly and carry out processes like muscle contraction and relaxation.

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Which two species are most closely related.?!?!

A.wolf and dog
B.dog and rabbit
C.giraffe and horse

Answers

a because they are the same creature but the dog is trained and the wolf isn't
Hello,

The answer is option A "wolf and dog".

Reason:

A wolf and a dog is the closest related animals (species).

If you need anymore help feel free to ask me!

Hope this helps!

~Nonportrit

Which type of nucleic acid is responsible for the transmission of information from the genetic code in the nucleus to the ribosome?

Answers

 Hey friend..

In some viruses, RNA contains the genetic information. RNA is of three types, they are tRNA (transfer RNA), mRNA (messenger RNA) and rRNA (ribosomal RNA). Messenger RNA, as the name suggests acts a messenger. It carries genetic information sequences between DNA and ribosomes, and it also directs protein synthesis.

hope it helps 

brainlliest?

What does temperature measure?

the number of atoms


the number of calories


the amount of heat energy


the amount of matter

Answers

Temperature is a measure of the average heat or thermal energy of the particles in a substance. Since it is an average measurement, it does not depend on the number of particles in an object. In that sense it does not depend on the size of it.

it is either the Number

of atoms or the amount of matter


Which forearm bone(s) contribute(s) most heavily to the elbow joint? the humerus the carpal bones the ulna the radius?

Answers

The bone is ulna. The ulna is a long bone found in the forearm that stretches from the elbow to the smallest finger, and when in anatomical position, is found on the medial side of the forearm. It runs parallel to the radius, the other long bone in the forearm, and is the larger and longer of the two. The radius or radial bone is one of the two large bones of the forearm, the other being the ulna. It extends from the lateral side of the elbow to the thumb side of the wrist and runs parallel to the ulna. The radius is shorter and smaller than the ulna.
Final answer:

The ulna and the radius bones contribute most heavily to the elbow joint.

Explanation:

The ulna and the radius bones contribute most heavily to the elbow joint.

The ulna is located on the medial aspect (pinky-finger side) of the forearm, and it is longer than the radius. It articulates with the humerus at the elbow. The radius is located along the lateral (thumb) side of the forearm and also articulates with the humerus at the elbow.

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Which of the following is the average height of the ocean’s surface between high and low tides?

-Sea level
-Sea rise
-Sea displacement
-Sea cycle

Answers

The average height of the oceans surface between high and low tides is called the sea level. It is important to know this measurement because with this it is possible that we can calculate the height of anything on the land. Also, we can  calculate the height of anything on the land. Also, we can be able to determine whether the oceans are falling or rising through time. 

So the answer is Sea level

The average height of the oceans surface between high and low tides is the sea level.

A talented artist is experiencing severe bipolar disorder. in terms of artistic output only, the best thing that artist could do is:

Answers

the artist could take the human to a docter

Increased activity of phosphodiesterase in a target cell would decrease its level of

Answers

The answer is cAMP or cyclic adenosine monophosphate. This is a derivative of ATP or adenosine triphosphate. It is a second messenger which is important in biological processes. This is used in signal transduction intracellularly, conveying the cAMP dependent pathway. This is formed from ATP through the action of the enzyme adenylate cyclase. Intracellular transduction can be used by hormones to exert its effects, regulation of ion channels, this can be used to activate protein kinases.

Collection of glands that secrete hormones into the blood which regulate growth, development, and homeostasis.

Answers

The answer is the endocrine system.

The brainest answer would be apprenticed.

When hair samples are taken, they are generally cut off about half way to the root.
a. True
b. False?

Answers

The answer is false.

Answer:

B. False

Explanation:

I took the test!!

Your patient is a​ 29-year-old man who works in a​ meat-processing plant. he received a knife wound in the proximal anteromedial​ thigh, which is continuing to bleed on your arrival. he is restless and thirsty and has​ pale, cool skin. he has a weak radial pulse of 130 and a blood pressure of​ 118/88 mmhg. this patient is exhibiting signs and symptoms consistent with a class​ ________ hemorrhage.

Answers

Your patient is a​ 29-year-old man who works in a​ meat-processing plant. he received a knife wound in the proximal anteromedial​ thigh, which is continuing to bleed on your arrival. he is restless and thirsty and has​ pale, cool skin. he has a weak radial pulse of 130 and a blood pressure of​ 118/88 mmhg. this patient is exhibiting signs and symptoms consistent with a class​  II hemorrhage.

- Class II hemorrhage i determined if a patient's blood loss ranges from 15 to 30% of the blood volume, and  Fluid resuscitation with crystalloid plus a  blood transfusion is a must with this type of patient.

Nuclei of atoms that make up a newborn baby were made in the

Answers

Nuclei of atoms which make up the newborn baby were made in ancient stars.

Ancient stars exploded many years ago and this is the same nuclei where newborn babies are being made.

Which group of humans is likely to experience the most devastating symptoms of toxoplasmosis?

the elderly
pregnant women
infants
unborn babies

Answers

The answer is unborn babies.

Toxoplasmosis can have serious consequences for unborn babies during pregnancy.

Toxoplasmosis is caused by the parasite Toxoplasma gondii and can lead to severe complications, especially in certain groups. Among the options provided, unborn babies are likely to experience the most devastating symptoms of toxoplasmosis if the infection occurs during pregnancy.

Why are defense systems needed in multicellular organisms?

Answers

We share an environment with many harmful organisms, so we need a way to protect ourselves

n the 1960s, new evidence helped support the theory of continental drift and change it into the theory of plate tectonics. What was this new evidence?

Answers

the new evidence that was found were the borders between the tectonic plates.

Compare/contrast Lamarck's explanation of evolution with Darwin's theory of evolution by natural selection.

Answers

Lamarck's theory postulates that traits are inherited to their descendants, Darwin's theory states traits are given by natural selection.

For Example, the majestic GIRAFFE! :-)

-Darwin's Theory says giraffes with long necks would be better suited for their African Savannah and would live and reproduce better than giraffes with short necks (natural selection). The short neck gene would.eventually die off.

-Lamarck's Theory says crave perfection. Giraffes with short necks would eventually grow longer necks instead of in Darwin's Theory, dying out. He then concludeds his theory that the giraffes with the better genes will get control over the gene pool aka the good genes are used more, but the bad genes don't just die out like in the other theory.

Hope this helps! :-)

Both Lamarks's theory and Darwin's theory both emphasize the evolution of species from simple life forms.

Evolution is the idea that complex life forms came from simple life forms. There are two basic approaches to the study of evolution;

Darwin's theoryLamark's theory

The main difference between the Darwin's theory and Lamark's theory is that Darwin's theory emphasized natural selection while the Lamark's theory emphasized the use and disuse of body parts.

However, the two theories provides a vital approach to studying the evolution of complex life forms from simple life forms:

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The client has difficulty swallowing and requests the nurse to crush all the medications. the nurse notes a client prescribed an extended-release opioid requests that all medications be crushed to facilitate the administration. what information about this form of opioid presents a problem respecting the client's request?

Answers

An extended-release medication is a drug with a different mechanism of release and action. The drug is designed to be released slowly over a course of time. It would not be a problem to crush an immediate-release drug but the nurse should not crush the extended-release opioid. If the patient receives this opioid medication crushed, the entire quantity of the drug will be at once released and active in its body. This could cause overdose or severe side-effects from the high dosage. 

A student is studying the ecology of a playa lake, which forms after a rainfall in a dry lake bed. the table lists the organisms that the student observed. which level of biological organization has the student described in the table?

Answers

The level of organization the student observed is community.

There are different levels of organization in Biology, more specifically Ecology, and these levels are listed below and explained in order from the highest to the lowest level.

The biosphere, which includes the largest part of the Earth, represents all living organisms on the land, in the ocean, and in the atmosphere.

An ecosystem is the next level of organization, which is a specific area with living organisms. It includes all the living organisms in that area but also the non-living environmental aspects, so it includes both biotic and abiotic factors.

A community includes all biotic factors of a specific area, so it is the biotic part of an ecosystem. This means that a community refers to all the populations of different species that live in a specific ecosystem and interact with each other.

A population is a level below a community, and above species, which refers to all of the individual organisms of one species that live in a specific community and interact with each other.

A species is a group of organisms that live in the same area, and interact with each other to breed, to produce viable offspring. All members of a species are genetically related and can be bred to produce fertile offspring.

Since the student in the example is observing a lake, which is an ecosystem, and he listed all the living organisms he found in that lake, we can conclude that the level of organization observed in the table is community. He described different shrimp species, and an insect species, and he didn't describe any abiotic factors, so that brings us to the level of community.

Antimicrobial agents that damage the viral envelope __________.

Answers

Antimicrobial agents that damage the viral envelope prevent attachment of the virus to its target cell. Viral envelopes allow the viruses to attach to cells so that they can replicate. Some viruses have viral envelopes covering their protective protein capsids. The envelope are typically derived from portions of the host cell membranes, but include some viral glycoproteins. They may help viruses avoid the host immune system. 
Final answer:

Antimicrobial agents that damage the viral envelope effectively inhibit viral growth without harming the host by disrupting the virus's ability to attach to and enter host cells.

Explanation:

Antimicrobial agents that damage the viral envelope are effective in inhibiting viral growth without damaging the host. These agents interfere with the integrity of the viral envelope, which is composed of lipids and proteins. By disrupting the envelope, the agents prevent the virus from attaching to and entering host cells, thereby inhibiting viral replication. One example of an antimicrobial agent that damages the viral envelope is Tamiflu, which inhibits the viral enzyme neuraminidase found in the influenza viral envelope.

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Which organisms is a secondary consumer in this food web?

Answers

In any food chain autotrophs are the producers which synthesizes food using solar energy. Autotrophs are green plants in terrestrial ecosystem. The herbivores which feed on plants are primary consumers and animals which feeds on herbivores are secondary consumer. These are carnivores or omnivores. For example, in forest ecosystem, trees are producers, deer is an primary consumer and lion is secondary or top consumer.    

Final answer:

In the Lake Ontario ecosystem food web, secondary consumers are typically carnivores that eat primary consumers. You would identify these organisms in the provided diagrams by looking for entities colored in blue. Examples might include certain species of small fish or birds.

Explanation:

In a food web, secondary consumers are typically carnivores that eat the primary consumers, which are herbivores. An organism that fits this description in the Lake Ontario ecosystem would be classified as blue in the provided food web diagrams. Since specific organisms aren't listed in your question, you would need to look for organisms colored in blue in the figures you've mentioned (Figure 37.6 or Figure 46.6) for the correct secondary consumers in that ecosystem.

Secondary consumers play a crucial role in the ecosystem by controlling the population of primary consumers and are themselves a food source for tertiary consumers. Examples of secondary consumers might include small fish or certain bird species that feed on primary consumers such as zooplankton or insects. Remember, in some ecosystems, some organisms may have a mixed diet that can place them in multiple trophic levels depending on their food choice at the time.

One scientist who attempted to explain how geological processes, such as rock layers, form and change over time was

Answers

One scientist who attempted to explain how rock layers form and change over time was... James Hutton.

I hope this is the answer you were looking for. I believe I’ve answered a question similar to this before!
~Brooke❤️

One scientist who attempted to explain how geological processes, such as rock layers, form and change over time was Charles Darwin, as he is one of the scientists who has given most of the prominent theories on the evolution of species.

What is the significance of Charles Darwin?

Charles Darwin made numerous contributions to the field of evolution, including proposing the theory of evolution by natural selection, which explains the origin of species, and providing a scientific explanation for life's diversity. Darwin has also made major contributions to the fields of biology, geology, and palaeontology.

Hence, one scientist who attempted to explain how geological processes, such as rock layers, form and change over time was Charles Darwin, as he is one of the scientists who has given most of the prominent theories on the evolution of species.

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A key is a sorting device that lists choices between certain observed characteristics. A dichotomous key is the simplest means of identification. The word dichotomy means "cut or split into two parts." Hence, a dichotomous key is a two-part or two-choice key. It asks whether a particular organism has one trait or another—either yellow or brown, either large or small, etc. For this project, you will classify different pieces of fruit by responding to dichotomous questions. In the fruit lab below, respond to the questions to help the computer identify all the pieces of fruit. After conducting the fruit lab, answer the following questions: What was your identification accuracy? Identify at least three types of characteristics that you were asked about as you helped the computer identify a fruit. How is the fruit lab like a dichotomous key?

Answers

What was your identification accuracy? 70%Identify at least three
types of characteristics that you were asked about as you helped the
computer identify a fruit. Is the exterior of the fruit reddish
including purple , is the fruit firm or soft How is the fruit lab like a dichotomous key , a dichotomous key is two paired sentences that are contrasting things
i wanna say its ....70%Identify at least threetypes of characteristics that you were asked about as you helped thecomputer identify a fruit. Is the exterior of the fruit reddishincluding purple , is the fruit firm or soft How is the fruit lab like a dichotomous key , a dichotomous key is two paired sentences that are contrasting things
not a 100% sure 

How does studying science help you be a better member of society? (1 point)

A. Learning the biases of science will help you know what is right or wrong.
B. Understanding how science works will help you make better decisions
C. Memorizing science facts will help you become more intelligent.
D. Knowing science will help you live without the aid of technology.


PLEASE HELP !!!

Answers

Understanding how science works will help you make better decisions.

The answer to this would be B) Understanding how science works will help you make better decisions!

The major disadvantage of a blood-brain barrier is that ____.​

Answers

The answer is a certain required chemicals must be actively transported.  Blood brain barrier is a selective membrane that separates blood circulating from the brain and the fluid of extracellular in the central nervous system. This is also called a filtering mechanism, the capillaries that carry blood to the brain and spinal cord tissue blocking the path way of the certain substance.

After mars the next most likely candidates for life in the solar system are

Answers

the large moons of the jovian planets

Which of the following most closely models the behavior of a sunspot?
A.
a freckle
B.
an eyelash
C.
a birthmark
D.
a lip

Answers

The answer is 
A.) A Freckle

Answer: A. a freckle

Explanation: hope this helps

3. How would you date a sample of rock that you suspect as being one of the earliest on Earth? (1 point)

Answers

If I were attempting to date a rock sample that I suspect to be incredibly old, i would use radioactive isotopes with a long half life. When dating rocks and fossils to discover approximately how old they are, radioisotope dating is used on igneous rocks found near fossils. Things like Uranium 235, which is an unstable radioactive isotope of elements, decays at a constant rate over time so can be useful in determining age.
Other Questions
Why are so many countries concerned about the growing globalization of the media? Children who are aggressive tend to come from families with _____ parenting styles 5. Jerry lost her credit card and instead of reporting it right away, she decides to continue looking for it for a couple of days. On the second day, she makes the call and reports the card lost/stolen to the credit card company. She then logs into the account activity page of her credit card and sees a recent $500 purchase that was made by someone else. How much of this $500 charge will Jerry have to pay? My grandmother gave me bad advice and good advice when I was in my early teens. For the bad advice, she said that I should become a barber because they made good money and listened to the radio all day. Honey, they dont work como burros, she would say every time I visited her. She made the sound of donkeys braying. Like that, honey! For the good advice, she said that I should marry a Mexican girl. No Okies, hijoshe would say Look, my son. He marry one and they fight every day about I dont know what and I dont know what. For her, everyone who wasnt Mexican, black, or Asian were Okies. The French were Okies, the Italians in suits were Okies. . . . she lectured me on the virtues of the Mexican girl. What inference can be made about the grandmothers point of view in this excerpt? What is the area of the triangle in the coordinate plane? A. 108 units B. 91 units C.54 units D.44 units When this unprecedented wave hit Wall Street in October of 1929 the false prosperity of the 1920s was over. a. buy orders c. margin orders b. sell orders d. mail orders A summary is a statement of a texts central ideas in one's When something is _______________, it means that is has more than one possible meaning or interpretation 4 Questions 1.) What is the purpose of a land grant? A. A land grant protects land for the exclusive use of the government B. A land grant always reserves property for native Americans only C. A land grant gives property to a certain person or group D. A land grant prevents the settlement or development of a certain area of land 2. Which of the following is NOT a type of land grant used in New Mexico? A. Pueblos B.Community grants C.State trust lands D.Colonies If the two equal sides of an isosceles triangle are 2 cm long, find the length of the third side thatmaximizes the area of the triangle. y=-2/9x+2turn this linear equation into standard form How did hinduism affect the way ancient indians lived day to day? What factors have the strongest influence on voting? which choice shows three lengths cannot be the lengths of the three sides of a trianglea. 2cm, 8cm, 8cmb. 2cm, 3cm, 6cmc. 4cm, 5cm, 7cm d. 5cm, 6cm, 9cm Review the stanza from "The Bat Poet":Curled at his breast, he sits there while the sunStripes the red westWith its last light: the chipmunkDives to his rest.Whichbestexplains how the stanza's structure contributes to the poem's meaning?The line lengths vary, which suggests the chipmunk's movement: quickly running, then stopping and watching for danger. There is little punctuation, which shows that the chipmunk lacks a formal education. The poem says that the chipmunk "dives to his rest," which shows that he is sluggish and unmotivated. The regular meter of the lines suggests the formal and calculated nature of the chipmunk's life. What is the average number of years of schooling for citizens of Nicaragua? Write the definition of a function minmax that has five parameters. the first three parameters are integers. the last two are set by the function to the largest and smallest of the values of the first three parameters. the function does not return a value. the function can be used as follows: int a=31, b=5, c=19 big, small; minmax(a,b,c,&big,&small); The pancreas is a human body organ that produces digestive enzymes and two very important hormones: insulin and glucagon. These two hormones work together to regulate the level of the sugar glucose in the bloodstream. If glucose levels in the bloodstream are too low, the pancreas secretes glucagon which causes the glucose level to increase. If blood glucose levels are too high, the hormone insulin will lower the glucose level. If a person has just eaten a meal containing a large amount of sugars and other carbohydrates, which statement BEST describes how the pancreas will respond? A)The amount of insulin produced by the pancreas will increase to reduce the amount of glucose in the bloodstream. B)The amount of insulin produced by the pancreas will decrease to allow the glucose levels in the blood to decrease. C)The amount of glucagon produced by the pancreas will decrease so that the amount of glucose in the bloodstream may increase. D)The amount of glucagon produced by the pancreas will increase to allow the sugars in the digestive tract to enter the bloodstream. The leading factor in the European colonization of Asia between 1500 and 1800 was the desire....A. to spread Christianity, B. to dominate and control trade, C. to modernize the culture of Asia, D. to import Asian slaves to work in western colonies, Select all that apply.What are three characteristics of the Agricultural Revolution?-More people were needed for farming.-Larger cities became a reality.-New tools made it possible for more crops to be grown.-Crop rotation was invented, making it harder on the soil.-Farmers learned to control water through canals and wells.,